Advanced regenerative architecture engineered to stabilize membrane performance, mitigate reversible fouling, and preserve the integrity of high-value shear-sensitive biofluids in GMP bioprocessing.

→ Watch the full technical video on TFF fouling mitigation

In-depth analysis of AFRM™ architecture and its impact on flux stabilization and permeability recovery.

Technical overview of AFRM™ — TFF fouling mitigation and process resilience for GMP biopharmaceutical manufacturing.

Alternatively, read the technical white paper.
Primary Application Areas

01 —

Gene Therapy

Viral Vector Filtration

AFRM™ addresses fouling at the mechanism level, maintaining sieving coefficient stability across the full batch duration.

McCarney L, et al. Sep. Purif. Technol. 2025. DOI

02 —

EV Therapeutics

Extracellular Vesicle Processing

Deterministic regeneration prevents the cake layer that would otherwise narrow effective pore diameter.

03 —

Perfusion Culture

High-Density Cell Retention

Maintains quasi-stationary flux throughout the campaign by preventing irreversible cake compaction.

04 —

mAb Downstream

Monoclonal Antibody Concentration

The regeneration schedule is pre-computed from fluid rheological parameters, eliminating empirical retuning.